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  • JOB
  • Netherlands

Postdoctoral researcher in genome stability and neurotoxicity

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4 Jun 2026

Job Information

Organisation/Company
Erasmus MC (University Medical Center Rotterdam)
Research Field
Medical sciences » Medicine
Neurosciences » Neurobiology
Neurosciences » Neurochemistry
Researcher Profile
Recognised Researcher (R2)
Application Deadline
Country
Netherlands
Type of Contract
Temporary
Job Status
Not Applicable
Hours Per Week
36.0
Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

Chemotherapy has greatly improved cancer survival, but many patients experience severe neurological side effects during or after treatment. These include peripheral neuropathy, causing numbness or pain in hands and feet, as well as cognitive problems often referred to as “chemobrain”, which can affect memory. These complications can persist long after treatment has ended, severely affecting quality of life and, in some cases, forcing dose reduction or therapy stop. Currently, there are no effective treatments to prevent these severe side effects.

In this KWF-funded project, we investigate how chemotherapy-induced DNA damage disrupts gene transcription in nerve cells and how this contributes to neurotoxicity. This project is a close collaboration between the labs of Jurgen Marteijn, Debbie van den Berg and Femke de Vrij, combining expertise in DNA damage and transcription stress with advanced human neuronal differentiation models. Using state-of-the-art neuronal differentiation models, live-cell imaging, DNA repair and functional neuronal assays, and genome-wide CRISPR screening, we aim to uncover the molecular mechanisms underlying chemotherapy-induced neurotoxicity and identify novel targets for therapeutic intervention. Ultimately, this work aims to contribute to new strategies that improve the long-term quality of life of cancer survivors.

Requirements

Specific Requirements

We are looking for a highly motivated candidate for a collaborative setting. This postdoctoral researcher will primarily focus on DNA damage-induced transcription stress and DNA repair mechanisms in neurons. Being able to present a certificate of good conduct, valid proof of identity and diplomas are conditions for the appointment.

  • You have a PhD degree in Biomedical or Life Sciences, Neuroscience or a related field.
  • You posess demonstrable skills in one of the following fields: ‘live cell imaging', ‘genome stability' or 'iPS culture and neural differentiation'.
  • You have excellent communication skills, both spoken and written in English.

Additional Information

Benefits
  • You will receive a temporary position for 3 years. The maximum gross monthly salary is € 5669,- (scale 10). The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).
  • A salary increase of 3,5% from July 2026, according to the collective labor agreement (cao).
  • Excellent fringe benefits, such as a 13th month that is already paid out in November and a personal travel allowance.
  • An International Office that supports you in preparing for you arrival and stay.
  • Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
  • Special benefits, such as an in-house physiotherapist and bicycle repair service. And there is also a gym where you can work on your fitness after work.
Additional comments

For more information about this position, please contact prof.dr. Jurgen Marteijn (j.marteijn@erasmusmc.nl). We aim to start this project on a short notice. For queries regarding your application, please contact Recruiter Tom Pleij (t.pleij@erasmusmc.nl).

If you are excited about this position and would like to apply, please submit your application including a CV, motivation letter, and contact details of at least two references before June 30th.

Website for additional job details

Work Location(s)

Number of offers available
1
Company/Institute
Erasmus MC
Country
Netherlands
City
Rotterdam
Postal Code
3015GD
Street
Dr. Molewaterplein 40

Contact

City
Rotterdam
Website
Street
Dr. Molewaterplein 40
Postal Code
3015 GD

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