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Nantes Université
  • JOB
  • France

PhD in organic chemistry – Synthesis of azaheterocyclic bioisosteres for the discovery and evaluation of novel BOB1/OCT2 interaction inhibitors (M/F)

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The Human Resources Strategy for Researchers
18 Jun 2026

Job Information

Organisation/Company
Nantes Université
Department
CEISAM UMR-CNRS 6230
Research Field
Chemistry » Organic chemistry
Researcher Profile
First Stage Researcher (R1)
Positions
PhD Positions
Application Deadline
Country
France
Type of Contract
Temporary
Job Status
Full-time
Hours Per Week
35
Offer Starting Date
Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?
No

Offer Description

The BOB1-OCT2 transcriptional complex is a lineage-specific master regulator of the germinal center B-cell program, driving both autoimmune pathologies and aggressive B-cell malignancies. Funded by the LABEX IMMUNE from NEXT/Nantes Université, this PhD project aims to synthesize and biologically evaluate small-molecule inhibitors of this protein-protein interaction.

This interdisciplinary consortium involves teams in medicinal chemistry (CEISAM-SYMBIOSE), immunology (CR2TI), and translational onco-hematology (CRCI2NA). The medicinal chemistry component will optimize initial hit molecules by introducing novel azaheterocyclic scaffolds through a scaffold-hopping strategy. Based on robust preliminary results, a synthetic chemistry work package is planned to validate the functionalization of azaheterocyclic structures.

As part of this drug design program, the PhD student will participate in the evaluation of molecules, which will be characterized to determine their efficacy in inhibiting the BOB1/OCT2 interaction and their pharmacological profiles. This series of novel compounds will be evaluated in various in vitro and in vivo models involving B immune cells (autoimmune diseases and cancer).

Project issues:

  • Original azaheterocyclic chemistry with high potential in pharmaceutical sciences
  • Characterization, drug design development, and biological evaluation of protein-protein interaction inhibitors
  • Application and valorization potential in autoimmune diseases (e.g., arthritis) and oncology (e.g., multiple myeloma).

Requirements

Research Field
Chemistry » Organic chemistry
Education Level
Master Degree or equivalent
Skills/Qualifications
  • Excellent skills in organic synthesis methodology and multi-step synthesis.
  • Strong expertise in physicochemical characterization. 
  • Keen interest in evolving within an interdisciplinary environment (biological evaluation/drug design and pharmacological assessments). 
  • Fluent in English
Languages
ENGLISH
Level
Good

Additional Information

Benefits

Interdisciplinary Consortium at Nantes Université with technical supervisions.:

  • (CEISAM, Organic & Medicinal Chemistry): Led by Dr Arnaud Tessier providing the medicinal chemistry engine driving rational redesign, scaffold hopping, SAR refinement, and physicochemical optimisation. 
  • (CR2TI, Team4, Immune regulation): Led by Dr Sophie Brouard, providing deep expertise in B-cell biology and autoimmunity, leading assay development, primary B-cell models, and autoimmune in vivo models. 
  • (CRCI2NA, Translational Onco-haematology): Led by Dr Catherine Pellat, providing expertise in high-risk B-cell malignancies with advanced functional assays to evaluate oncological mechanisms and biomarker signatures.
Selection process

Candidate will have to submit the following documents:

  • Detailed and updated CV
  • Cover letter
  • Transcripts of the grades and rankings of the Master’s degree or engineering degree (for semesters for which grades are available)
  • Letter of appreciation from the direct supervisor of the Master’s research internship (mandatory for the 2nd year of the Master's degree, if applicable for the 1st year)

Pre-selected candidates will be contacted directly for an interview with a committee composed of at least the thesis director and a representative of the Graduate School

Work Location(s)

Number of offers available
1
Company/Institute
CEISAM UMR-CNRS 6230
Country
France
City
NANTES
Postal Code
44100
Street
2 Rue de la Houssinière
Geofield

Contact

State/Province
FRANCE
City
NANTES
Website
Street
1 QUAI DE TOURVILLE, BP 13522, 44035 NANTES CEDEX 01
E-Mail
Arnaud.Tessier@univ-nantes.fr
Sophie.Brouard@univ-nantes.fr

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